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That engineering system relies upon a \u201cdiversity generator\u201d that...<a class="vbp-toggle-more tradevibes_toggle_button discovery_interesting" onclick="tradevibes_toggle_description(event);">More&raquo;</a></p>\n\t\t\t<p class="vbp-description vbp-description-long vbp-hide tradevibes_hidden">AvidBiotics is using a new type of protein engineering to develop molecules that can successfully attack drug-resistant bacterial. That engineering system relies upon a \u201cdiversity generator\u201d that produces a variety of modifications in protein structure that affect the molecules\u2019 ability to bind to and attack various surface molecules on bacteria. Screening the new proteins created this way allows researchers to identify the ones with the best drug-like properties. The idea is similar in certain respects to \u201ccombinatorial chemistry,\u201d an attempt to harness an evolution-like mechanism in the development of small-molecule drugs.  The company\u2019s first target is Pseudomonas aeruginosa, an opportunistic bacteria that attacks immunocompromised tissues. It can cause infections of the skin, the urinary tract, the digestive system, and many other organ systems.<a class="vbp-toggle-more tradevibes_toggle_button discovery_interesting" onclick="tradevibes_toggle_description(event);">&laquo;Less</a></p>\n\n\t\t\t<div class="vbp-category">\n\t\t\t\t<h5>Overview</h5>\n\t\t\t\t<p><strong>Location:</strong> \tSouth San Francisco, CA, United States\n</p>\n\t\t\t\t<p><strong>Industry:</strong> Biopharmaceuticals</p>\n\t\t\t\t<p><strong>Tags:</strong>\n\t\t\t\t<a href="http://venturebeatprofiles.com/company/tag_list?tag=biotech">biotech</a>,\n\t\t\t\t<a href="http://venturebeatprofiles.com/company/tag_list?tag=life+science">life science</a>,\n\t\t\t\t<a href="http://venturebeatprofiles.com/company/tag_list?tag=biotherapeutics">biotherapeutics</a>,\n\t\t\t\t<a href="http://venturebeatprofiles.com/company/tag_list?tag=bacterial+disease">bacterial disease</a>\n\t\t\t\t</p>\n\t\t\t</div>\n\n\t\t</div><!-- col -->\n\t\t<div class="vbp-right-col vbp-col">\n\n\n\t\t</div><!-- col -->\n\t</div><!-- content -->\n\t<p class="vbp-footer">\n\t\t<a href="http://venturebeatprofiles.com/company/profile/avidbiotics?src=widget">AvidBiotics Company Profile</a> powered by <a href="http://venturebeatprofiles.com/?src=widget">VentureBeat Profiles</a>.\n\t</p>\n</div><!-- widget -->\n'
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